Towards a cell-based model of Neointimal Hyperplasia with Cellular Potts Model MSc thesis
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چکیده
منابع مشابه
Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia.
OBJECTIVE Phosphoinositide (PI) 3-kinase promotes vascular smooth muscle cell (VSMC) responses necessary for neointimal hyperplasia. We recently demonstrated that the inositol 3-phosphatase PTEN is expressed in VSMCs and that its overexpression inhibits these cellular responses. The purpose of this study was to determine the effects of adenovirus-mediated overexpression of PTEN on neointimal hy...
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INTRODUCTION Neointimal hyperplasia remains an important problem after stent implantation. Previous investigations examining vascular responses to stent implantation and effects of drugs have used a retrograde deployment approach that may inadvertently alter the local fluid dynamics surrounding the stent. We present a model of antegrade iliac artery stent implantation that facilitates the analy...
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BACKGROUND Stent-based delivery of sirolimus (SRL) has shown reduction in neointimal hyperplasia and restenosis. The purpose of this study was to evaluate the chronic vascular response and the expression of cell cycle regulators after SRL-eluting stent implantation in a porcine coronary model. METHODS Forty-nine pigs underwent placement of 109 oversized stents (control, n=54, SRL (140 microg/...
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تاریخ انتشار 2011